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Thereactions they catalyze are often described by their chemistry,but with only a few exceptions, most are oxidations, as can beseen by the addition of an oxygen atom in the basic chemicalreactions (Table 2.2).

Interestingly, tumors that arise in MAP do not have thewidespread chromosomal instability that is typical of FAP and many sporadictumors, nor do they have the microsatellite instability that de?nes Lynch Syndrome.In this way they are a discrete subtype of colorectal cancer, but their relatively recentdiscovery and the small numbers of patients affected means that there are little data onpatient outcomes. Many clinicians empirically recommend avoiding immunizations within 2weeks of BoNT injections to avoid stimulating the patient’s immune system (18)

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In the B “experimental” seg-ment, the experimental treatment is introduced, and several more repeated measurementsof the dependent variable are made. If normal saline is not available, tap water is used

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Electron micrograph ofafreezefracture replica showsthe E-faceofthe membrane ofoneepithelial cell and the P-face ofthe membrane ofthe adjoining cell.The cleavage plane hasjumped from the membrane ofone cell to the membraneofthe other cell,as indicated bythe clear space (intercellular space)acrossthe middleofthe figure.

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